Donald Trump and his top allies quickly jumped on a hotter-than-expected inflation report Thursday to slam the Biden-Harris administration, the Federal Reserve, and central bank chairman Jerome Powell.

"The fact is that the Federal Reserve brought the interest rates down a little too quickly," former President Donald Trump said Thursday afternoon during an appearance at the Detroit Economic Club.

"It was too big a cut and everyone knows that was a political maneuver that they tried to do before the election," he added.

It was the most direct critique from Trump of Powell in months and came after an initial reaction from the GOP nominee to the September interest rate cut of 50 basis points in which Trump often focused on charges of a bad economy over critiquing the central bank directly.

“It was totally a political decision and inflation has started to rise,” Trump said Thursday while also charging that high interest rates "really kills the American dream for young people."

Make America Great Again, Inc. — a Trump-supporting Super-PAC — also jumped in with a release Thursday saying Thursday's inflation reading could be part of "the Fed's worst nightmare."

Overall, prices, as measured by the Consumer Price Index, increased 2.4% over the last year, which marked a slight deceleration following August's 2.5% annual gain in prices.

Read more: Jobs, inflation, and the Fed: How they're all related

But the lower annual readings were largely overshadowed by a monthly increase in September of 0.2% over August, hotter than economist estimates of a 0.1% uptick.

Democrats, including the Biden-Harris administration, chose to focus on that annual number in their reactions, with national economic adviser Lael Brainard offering in a statement that "inflation has fallen back down to 2.4%, the same rate as right before the pandemic."

"We keep making progress," she added.

Political headaches for Powell

The Federal Reserve’s Open Market Committee won’t gather again until after Election Day. Thursday's inflation reading appeared to offer new momentum for central bank hawks counseling a more gradual pace of interest rate cuts in the months ahead.

And some initial reactions suggested a change in strategy is not likely no matter what Trump says.

Likely 25 basis point cuts at the last two meetings of the year are "pretty much baked into the cake," Max Kettner, HSBC chief multi-asset strategist, offered in a Yahoo Finance video interview Thursday.

But Atlanta Fed president Raphael Bostic did tell The Wall Street Journal Thursday following the CPI release that he was “totally comfortable” with holding steady next month and that he had already penciled in an estimate of just one more rate cut this year.