Kymera Therapeutics Inc (KYMR) Q3 2024 Earnings Call Highlights: Strategic Advancements and ...

GuruFocus News
3 min read

In This Article:

  • Revenue: $3.7 million, all attributable to Sanofi collaboration.

  • R&D Spending: $61 million, excluding non-cash stock-based compensation, down about 2% sequentially from the June quarter.

  • Cash Balance: $911 million, providing a cash runway to mid-2027.

Release Date: October 31, 2024

For the complete transcript of the earnings call, please refer to the full earnings call transcript.

Positive Points

  • Kymera Therapeutics Inc (NASDAQ:KYMR) has advanced KT-621 into the clinic, marking a significant milestone with a promising drug profile.

  • The company has raised approximately $600 million in 2024, providing a cash runway into mid-2027.

  • Kymera Therapeutics Inc (NASDAQ:KYMR) is progressing with multiple phase two B trials for KT-474, in collaboration with Sanofi, which could accelerate the path to phase three studies.

  • The company is advancing KT-295 as a lead clinical candidate, showing greater in vivo activity compared to KT-294, without impacting development timelines.

  • Kymera Therapeutics Inc (NASDAQ:KYMR) is focusing resources on expanding its immunology pipeline, which has the potential to create outsized value.

Negative Points

  • There were technical difficulties during the earnings call, which may have impacted the clarity of some updates.

  • The transition to phase two B studies for KT-474 extends the timeline for complete phase two data readout to 2026.

  • Kymera Therapeutics Inc (NASDAQ:KYMR) has decided not to advance certain oncology programs beyond phase one, which may limit its oncology pipeline.

  • The company faces competition in the stat six degradation space, with other companies also pursuing similar targets.

  • There is uncertainty regarding the differentiation of Kymera Therapeutics Inc (NASDAQ:KYMR)'s stat six degrader compared to other approaches, such as small molecule inhibitors.

Q & A Highlights

Q: How reliable are changes in IgE and TC from the healthy volunteer study for KT-621, and how do they compare to previous studies? A: Nello Mainolfi, CEO, explained that the main goal of the phase one study is to demonstrate predictable PK and safety. The study uses a direct biomarker, protein levels, which is more reliable than downstream biomarkers. Changes in IgE and TC are modest in healthy volunteers, and while they provide some insight, the primary focus is on safety and PK. The expected changes are in line with previous studies, but the data can be noisy.

Q: With the focus on immunology, are there any savings from oncology that will be redeployed? A: Bruce Jacobs, CFO, stated that there are savings from not pursuing certain oncology clinical development plans. However, most of these savings will be reinvested into the immunology pipeline, including both disclosed and undisclosed programs. The overall cash runway guidance remains unchanged.

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