With Alzheimer’s disease affecting over 50 million people globally and projections rising to over 113 million by 2050, there is an urgent need for innovative therapies that address the root causes of cognitive decline. Current treatments primarily focus on managing symptoms, but Nexalin’s DIFS technology offers the potential to modulate brain activity and restore metabolic functions, providing a new avenue for treating this debilitating disease.

This study builds on the recently announced findings from Nexalin’s DIFS research, which demonstrated similar improvements in memory and cognitive function in Alzheimer’s patients. The DIFS study revealed significant gains in Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores, along with increased neural activity and blood flow in the hippocampus, a region critical for memory. By confirming these cognitive improvements and extending them to broader brain networks, this new study strengthens the case for non-invasive stimulation therapies like DIFS in Alzheimer’s treatment.

Dr. David Owens, Chief Medical Officer at Nexalin, commented: “We are very encouraged by the findings of this study, which reaffirm that DIFS not only improves cognitive function but also does so in a well-tolerated manner, even in elderly populations. The connections between brain activity, blood flow, and glucose metabolism suggest that DIFS may be addressing some of the underlying causes of cognitive decline in Alzheimer’s patients, offering hope for long-term improvements.”

Mark White, CEO of Nexalin Technology, added: “This study marks another significant milestone for Nexalin’s DIFS technology. Building on our recent DIFS findings, these results further demonstrate the potential of our non-invasive brain stimulation methods to restore brain function and improve cognitive performance in Alzheimer’s patients. With the efficacy shown in these studies, we are professionally optimistic regarding the future of DIFS as a treatment option that directly targets the brain’s electrical activity to help slow the progression of this devastating disease.”

About Nexalin Technology, Inc.

Nexalin designs and develops innovative neurostimulation products to uniquely help combat the ongoing global mental health epidemic. All of Nexalin’s products are believed to be non-invasive and undetectable to the human body and are developed to provide relief to those afflicted with mental health issues. Nexalin utilizes bioelectronic medical technology to treat mental health issues. Nexalin believes its neurostimulation medical devices can penetrate structures deep in the mid-brain that are associated with mental health disorders. Nexalin believes the deeper-penetrating waveform in its next-generation devices will generate enhanced patient response without any adverse side effects. The Nexalin Gen-2 15 milliamp neurostimulation device has been approved in China, Brazil, and Oman.  Additional information about the Company is available at: https://nexalin.com/.

Disclaimers

This study was conducted on a limited number of participants, and larger clinical trials are needed to confirm the efficacy and safety of DIFS for Alzheimer's disease. The information in this press release is for informational purposes only and does not constitute medical advice.

Forward-looking statements

This press release contains statements that constitute “forward-looking statements,” These statements relate to future events or Nexalin’s future financial performance. Any statements that refer to expectations, projections or other characterizations of future events or circumstances or that are not statements of historical fact (including without limitation statements to the effect that Nexalin or its management “believes”, “expects”, “anticipates”, “plans”, “intends” and similar expressions) should be considered forward looking statements that involve risks and uncertainties which could cause actual events or Nexalin’s actual results to differ materially from those indicated by the forward-looking statements.  Forward-looking statements are subject to numerous conditions, many of which are beyond the control of the Company, including those set forth in the Risk Factors section of the Company's Report on Form 10-K for the year ended December 31, 2023 and other filings as filed with the Securities and Exchange Commission. Copies of such filings are available on the SEC’s website, www.sec.gov. Such forward-looking statements are made as of the date hereof and may become outdated over time. Such forward-looking statements are made as of the date hereof and may become outdated over time. The Company undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law.

Contact:
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ⁱ Wang, T., Yan, S., Shan, Y., Xing, Y., Bi, S., Chen, Z., Xi, H., Xue, H., Qi, Z., Tang, Y., Lu, J. (2024).
Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer's Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study. Journal of Alzheimer's Disease, 101(3), 901-912. doi: 10.3233/JAD-240400.