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Investment bank Morgan Stanley issued an "underweight" warning on Mexican shares on Wednesday due to concerns about planned changes to the judiciary and electoral system, and also downgraded forecasts for China's main markets. The effective "sell" recommendation on Mexico comes as outgoing president Andres Manuel Lopez Obrador looks to push through a bevy of constitutional reforms with the help of his soon-to-be successor Claudia Sheinbaum. The most controversial is judicial reform, which aims at having a new system where all judges — including Supreme Court magistrates — would be elected by popular vote.
Tuesday, Aadi Bioscience Inc. (NASDAQ:AADI) announced it will halt the registration-intended PRECISION1 trial of nab-sirolimus in patients with solid tumors harboring TSC1 or TSC2 inactivating alterations. An analysis by the Independent Data Monitoring Committee demonstrated that the study was unlikely to exceed an efficacy threshold necessary to support an accelerated approval, the key goal of this Phase 2 study. The approximately 25 patients in PRECISION1 still benefiting from nab-sirolimus wi