Nykode Therapeutics Announces Updates on its Inverse Vaccine Platform at FOCIS 2024 Meeting
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OSLO, Norway, June 20, 2024 (GLOBE NEWSWIRE) -- Nykode Therapeutics ASA (OSE: NYKD), a clinical-stage biopharmaceutical company dedicated to the discovery and development of novel immunotherapies, today announced advancements in its inverse vaccine platform at the annual Federation of Clinical Immunology Societies (FOCIS) meeting in San Francisco.
Building on findings previously announced in March at the Antigen-Specific Immune Tolerance Summit in Boston, Nykode presented extended therapeutic data from the experimental autoimmune encephalomyelitis (EAE) model of Multiple Sclerosis (MS). The updates included demonstrating the disease-modifying effects of two distinct targeting units within its inverse vaccine platform in a therapeutic regimen, highlighting the versatility and effectiveness of antigen-presenting cell (APC)-targeting strategies.
At the conference, Nykode presented data, demonstrating a dose-dependent and disease-modifying effect of its antigen-specific APC-targeting vaccine in a therapeutic regimen, compared to the delivery of antigen alone, emphasizing the platform’s potential for effective antigen-specific treatment for autoimmune disorders.
There are approximately 100 different autoimmune diseases affecting about 4% of the world population, representing a significant unmet medical need for novel treatments. Nykode is focusing on developing antigen-specific treatments for autoimmune diseases by using its APC-targeting platform to deliver a tolerogenic response towards disease-associated antigens.
"These findings represent progress in our ongoing research into inverse vaccines and autoimmune disease treatment," said Agnete Fredriksen, Chief Scientific Officer and Co-founder of Nykode. "By exploring different targeting units and their impact compared to antigen delivery, Nykode aims to refine therapies that could offer new options for autoimmune conditions, aiming to develop a new class of drugs that are antigen-specific, with the potential to be both long-lasting and have limited side effects."
"We are excited about the progress and promise of Nykode’s inverse vaccine platform for the treatment of autoimmune diseases. We are planning initiatives to advance our efforts, including establishing a subsidiary within Nykode focused on further progressing the immune tolerance platform. This would allow a clear focus and increased visibility of the value we believe is associated with the technology. It will also serve as preparation for new partnerships and potential direct ownership amongst Nykode shareholders," added Michael Engsig, CEO.